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KMID : 0921620120420020162
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Journal of Bacteriology and Virology
2012 Volume.42 No. 2 p.162 ~ p.168
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Possible Roles of UL112-113 Proteins in Human Cytomegalovirus DNA Replication
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Kim Young-Eui
Ahn Jin-Hyun
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Abstract
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DNA replication of human cytomegalovirus (HCMV) is a highly regulated process that requires specific interactions between cis-acting lytic origin of replication (oriLyt) and trans-acting viral proteins. Formation of the replication initiation complex is also regulated by specific interactions among viral replication proteins. HCMV replication proteins include origin-binding proteins, core proteins that work in replication forks, and regulatory proteins that modulate host cell functions. This letter describes intriguing questions regarding how HCMV origin-binding proteins interact with oriLyt to initiate DNA replication and how the regulatory UL112-113 proteins, which are found only in beta-herpesviruses, function to promote viral DNA replication.
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KEYWORD
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HCMV, DNA replication, UL112-113
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